Evidence for the role of EPHX2 gene variants in anorexia nervosa.
Identifieur interne : 002F25 ( Main/Exploration ); précédent : 002F24; suivant : 002F26Evidence for the role of EPHX2 gene variants in anorexia nervosa.
Auteurs : A A Scott-Van Zeeland [États-Unis] ; C S Bloss [États-Unis] ; R. Tewhey [États-Unis] ; V. Bansal [États-Unis] ; A. Torkamani [États-Unis] ; O. Libiger [États-Unis] ; V. Duvvuri [États-Unis] ; N. Wineinger [États-Unis] ; L. Galvez [États-Unis] ; B F Darst [États-Unis] ; E N Smith [États-Unis] ; A. Carson [États-Unis] ; P. Pham [États-Unis] ; T. Phillips [États-Unis] ; N. Villarasa [États-Unis] ; R. Tisch [États-Unis] ; G. Zhang [États-Unis] ; S. Levy [États-Unis] ; S. Murray [États-Unis] ; W. Chen [États-Unis] ; S. Srinivasan [États-Unis] ; G. Berenson [États-Unis] ; H. Brandt [États-Unis] ; S. Crawford [États-Unis] ; S. Crow [États-Unis] ; M M Fichter [Allemagne] ; K A Halmi [États-Unis] ; C. Johnson [États-Unis] ; A S Kaplan [Canada] ; M. La Via [États-Unis] ; J E Mitchell [États-Unis] ; M. Strober [États-Unis] ; A. Rotondo [Italie] ; J. Treasure [Royaume-Uni] ; D B Woodside [États-Unis] ; C M Bulik [États-Unis] ; P. Keel [États-Unis] ; K L Klump [États-Unis] ; L. Lilenfeld [États-Unis] ; K. Plotnicov [États-Unis] ; E J Topol [États-Unis] ; P B Shih [États-Unis] ; P. Magistretti [Suisse] ; A W Bergen [États-Unis] ; W. Berrettini [États-Unis] ; W. Kaye [États-Unis] ; N J Schork [États-Unis]Source :
- Molecular psychiatry [ 1476-5578 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anorexie mentale (génétique), Anorexie mentale (métabolisme), Cholestérol (métabolisme), Epoxide hydrolase (génétique), Femelle, Humains, Indice de masse corporelle, Jeune adulte, Mâle, Polymorphisme de nucléotide simple, Population d'origine européenne (génétique), Prédisposition génétique à une maladie, Psychométrie, Variation génétique, Études cas-témoins, Études de cohortes, Études longitudinales.
- MESH :
- génétique : Anorexie mentale, Epoxide hydrolase, Population d'origine européenne.
- métabolisme : Anorexie mentale, Cholestérol.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de masse corporelle, Jeune adulte, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Psychométrie, Variation génétique, Études cas-témoins, Études de cohortes, Études longitudinales.
English descriptors
- KwdEn :
- Adult, Anorexia Nervosa (genetics), Anorexia Nervosa (metabolism), Body Mass Index, Case-Control Studies, Cholesterol (metabolism), Cohort Studies, Epoxide Hydrolases (genetics), European Continental Ancestry Group (genetics), Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Longitudinal Studies, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychometrics, Young Adult.
- MESH :
- chemical , genetics : Epoxide Hydrolases.
- chemical , metabolism : Cholesterol.
- genetics : Anorexia Nervosa, European Continental Ancestry Group.
- metabolism : Anorexia Nervosa.
- Adult, Body Mass Index, Case-Control Studies, Cohort Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Longitudinal Studies, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychometrics, Young Adult.
Abstract
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.
DOI: 10.1038/mp.2013.91
PubMed: 23999524
Affiliations:
- Allemagne, Canada, Italie, Royaume-Uni, Suisse, États-Unis
- Angleterre, Californie, Canton de Vaud, Caroline du Nord, Colorado, Dakota du Nord, District de Columbia, Floride, Grand Londres, Louisiane, Maryland, Michigan, Minnesota, Pennsylvanie, Toscane, État de New York
- Chapel Hill (Caroline du Nord), East Lansing, Lausanne, Londres, Pise, Pittsburgh
- Université d'État du Michigan, Université de Caroline du Nord à Chapel Hill, Université de Londres, Université de Pise, Université de Pittsburgh
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002A58
- to stream PubMed, to step Curation: 002A45
- to stream PubMed, to step Checkpoint: 002A45
- to stream Ncbi, to step Merge: 000240
- to stream Ncbi, to step Curation: 000240
- to stream Ncbi, to step Checkpoint: 000240
- to stream Main, to step Merge: 003062
- to stream Main, to step Curation: 002F25
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence for the role of EPHX2 gene variants in anorexia nervosa.</title><author><name sortKey="Scott Van Zeeland, A A" sort="Scott Van Zeeland, A A" uniqKey="Scott Van Zeeland A" first="A A" last="Scott-Van Zeeland">A A Scott-Van Zeeland</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bloss, C S" sort="Bloss, C S" uniqKey="Bloss C" first="C S" last="Bloss">C S Bloss</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tewhey, R" sort="Tewhey, R" uniqKey="Tewhey R" first="R" last="Tewhey">R. Tewhey</name><affiliation wicri:level="2"><nlm:affiliation>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bansal, V" sort="Bansal, V" uniqKey="Bansal V" first="V" last="Bansal">V. Bansal</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Torkamani, A" sort="Torkamani, A" uniqKey="Torkamani A" first="A" last="Torkamani">A. Torkamani</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Libiger, O" sort="Libiger, O" uniqKey="Libiger O" first="O" last="Libiger">O. Libiger</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Duvvuri, V" sort="Duvvuri, V" uniqKey="Duvvuri V" first="V" last="Duvvuri">V. Duvvuri</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wineinger, N" sort="Wineinger, N" uniqKey="Wineinger N" first="N" last="Wineinger">N. Wineinger</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Galvez, L" sort="Galvez, L" uniqKey="Galvez L" first="L" last="Galvez">L. Galvez</name><affiliation wicri:level="2"><nlm:affiliation>The Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Darst, B F" sort="Darst, B F" uniqKey="Darst B" first="B F" last="Darst">B F Darst</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Smith, E N" sort="Smith, E N" uniqKey="Smith E" first="E N" last="Smith">E N Smith</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Carson, A" sort="Carson, A" uniqKey="Carson A" first="A" last="Carson">A. Carson</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pham, P" sort="Pham, P" uniqKey="Pham P" first="P" last="Pham">P. Pham</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Phillips, T" sort="Phillips, T" uniqKey="Phillips T" first="T" last="Phillips">T. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Villarasa, N" sort="Villarasa, N" uniqKey="Villarasa N" first="N" last="Villarasa">N. Villarasa</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tisch, R" sort="Tisch, R" uniqKey="Tisch R" first="R" last="Tisch">R. Tisch</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhang, G" sort="Zhang, G" uniqKey="Zhang G" first="G" last="Zhang">G. Zhang</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Levy, S" sort="Levy, S" uniqKey="Levy S" first="S" last="Levy">S. Levy</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Murray, S" sort="Murray, S" uniqKey="Murray S" first="S" last="Murray">S. Murray</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W" last="Chen">W. Chen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Srinivasan, S" sort="Srinivasan, S" uniqKey="Srinivasan S" first="S" last="Srinivasan">S. Srinivasan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Berenson, G" sort="Berenson, G" uniqKey="Berenson G" first="G" last="Berenson">G. Berenson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Brandt, H" sort="Brandt, H" uniqKey="Brandt H" first="H" last="Brandt">H. Brandt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crawford, S" sort="Crawford, S" uniqKey="Crawford S" first="S" last="Crawford">S. Crawford</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crow, S" sort="Crow, S" uniqKey="Crow S" first="S" last="Crow">S. Crow</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Minnesota, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Fichter, M M" sort="Fichter, M M" uniqKey="Fichter M" first="M M" last="Fichter">M M Fichter</name><affiliation wicri:level="1"><nlm:affiliation>Roseneck Hospital for Behavioral Medicine, Prien, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Roseneck Hospital for Behavioral Medicine, Prien</wicri:regionArea><wicri:noRegion>Prien</wicri:noRegion><wicri:noRegion>Prien</wicri:noRegion><wicri:noRegion>Prien</wicri:noRegion></affiliation></author><author><name sortKey="Halmi, K A" sort="Halmi, K A" uniqKey="Halmi K" first="K A" last="Halmi">K A Halmi</name><affiliation wicri:level="2"><nlm:affiliation>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C" last="Johnson">C. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Eating Recovery Center, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eating Recovery Center, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Kaplan, A S" sort="Kaplan, A S" uniqKey="Kaplan A" first="A S" last="Kaplan">A S Kaplan</name><affiliation wicri:level="1"><nlm:affiliation>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="La Via, M" sort="La Via, M" uniqKey="La Via M" first="M" last="La Via">M. La Via</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Mitchell, J E" sort="Mitchell, J E" uniqKey="Mitchell J" first="J E" last="Mitchell">J E Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND</wicri:regionArea><placeName><region type="state">Dakota du Nord</region></placeName></affiliation></author><author><name sortKey="Strober, M" sort="Strober, M" uniqKey="Strober M" first="M" last="Strober">M. Strober</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rotondo, A" sort="Rotondo, A" uniqKey="Rotondo A" first="A" last="Rotondo">A. Rotondo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Treasure, J" sort="Treasure, J" uniqKey="Treasure J" first="J" last="Treasure">J. Treasure</name><affiliation wicri:level="4"><nlm:affiliation>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Woodside, D B" sort="Woodside, D B" uniqKey="Woodside D" first="D B" last="Woodside">D B Woodside</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bulik, C M" sort="Bulik, C M" uniqKey="Bulik C" first="C M" last="Bulik">C M Bulik</name><affiliation wicri:level="4"><nlm:affiliation>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Keel, P" sort="Keel, P" uniqKey="Keel P" first="P" last="Keel">P. Keel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Klump, K L" sort="Klump, K L" uniqKey="Klump K" first="K L" last="Klump">K L Klump</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Lilenfeld, L" sort="Lilenfeld, L" uniqKey="Lilenfeld L" first="L" last="Lilenfeld">L. Lilenfeld</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Plotnicov, K" sort="Plotnicov, K" uniqKey="Plotnicov K" first="K" last="Plotnicov">K. Plotnicov</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Topol, E J" sort="Topol, E J" uniqKey="Topol E" first="E J" last="Topol">E J Topol</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shih, P B" sort="Shih, P B" uniqKey="Shih P" first="P B" last="Shih">P B Shih</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Magistretti, P" sort="Magistretti, P" uniqKey="Magistretti P" first="P" last="Magistretti">P. Magistretti</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bergen, A W" sort="Bergen, A W" uniqKey="Bergen A" first="A W" last="Bergen">A W Bergen</name><affiliation wicri:level="2"><nlm:affiliation>Center for Health Sciences, SRI International, Menlo Park, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health Sciences, SRI International, Menlo Park, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Berrettini, W" sort="Berrettini, W" uniqKey="Berrettini W" first="W" last="Berrettini">W. Berrettini</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kaye, W" sort="Kaye, W" uniqKey="Kaye W" first="W" last="Kaye">W. Kaye</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schork, N J" sort="Schork, N J" uniqKey="Schork N" first="N J" last="Schork">N J Schork</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23999524</idno><idno type="pmid">23999524</idno><idno type="doi">10.1038/mp.2013.91</idno><idno type="wicri:Area/PubMed/Corpus">002A58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A58</idno><idno type="wicri:Area/PubMed/Curation">002A45</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A45</idno><idno type="wicri:Area/PubMed/Checkpoint">002A45</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A45</idno><idno type="wicri:Area/Ncbi/Merge">000240</idno><idno type="wicri:Area/Ncbi/Curation">000240</idno><idno type="wicri:Area/Ncbi/Checkpoint">000240</idno><idno type="wicri:Area/Main/Merge">003062</idno><idno type="wicri:Area/Main/Curation">002F25</idno><idno type="wicri:Area/Main/Exploration">002F25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence for the role of EPHX2 gene variants in anorexia nervosa.</title><author><name sortKey="Scott Van Zeeland, A A" sort="Scott Van Zeeland, A A" uniqKey="Scott Van Zeeland A" first="A A" last="Scott-Van Zeeland">A A Scott-Van Zeeland</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bloss, C S" sort="Bloss, C S" uniqKey="Bloss C" first="C S" last="Bloss">C S Bloss</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tewhey, R" sort="Tewhey, R" uniqKey="Tewhey R" first="R" last="Tewhey">R. Tewhey</name><affiliation wicri:level="2"><nlm:affiliation>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bansal, V" sort="Bansal, V" uniqKey="Bansal V" first="V" last="Bansal">V. Bansal</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Torkamani, A" sort="Torkamani, A" uniqKey="Torkamani A" first="A" last="Torkamani">A. Torkamani</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Libiger, O" sort="Libiger, O" uniqKey="Libiger O" first="O" last="Libiger">O. Libiger</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Duvvuri, V" sort="Duvvuri, V" uniqKey="Duvvuri V" first="V" last="Duvvuri">V. Duvvuri</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wineinger, N" sort="Wineinger, N" uniqKey="Wineinger N" first="N" last="Wineinger">N. Wineinger</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Galvez, L" sort="Galvez, L" uniqKey="Galvez L" first="L" last="Galvez">L. Galvez</name><affiliation wicri:level="2"><nlm:affiliation>The Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Darst, B F" sort="Darst, B F" uniqKey="Darst B" first="B F" last="Darst">B F Darst</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Smith, E N" sort="Smith, E N" uniqKey="Smith E" first="E N" last="Smith">E N Smith</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Carson, A" sort="Carson, A" uniqKey="Carson A" first="A" last="Carson">A. Carson</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pham, P" sort="Pham, P" uniqKey="Pham P" first="P" last="Pham">P. Pham</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Phillips, T" sort="Phillips, T" uniqKey="Phillips T" first="T" last="Phillips">T. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Villarasa, N" sort="Villarasa, N" uniqKey="Villarasa N" first="N" last="Villarasa">N. Villarasa</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tisch, R" sort="Tisch, R" uniqKey="Tisch R" first="R" last="Tisch">R. Tisch</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhang, G" sort="Zhang, G" uniqKey="Zhang G" first="G" last="Zhang">G. Zhang</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Levy, S" sort="Levy, S" uniqKey="Levy S" first="S" last="Levy">S. Levy</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Murray, S" sort="Murray, S" uniqKey="Murray S" first="S" last="Murray">S. Murray</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W" last="Chen">W. Chen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Srinivasan, S" sort="Srinivasan, S" uniqKey="Srinivasan S" first="S" last="Srinivasan">S. Srinivasan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Berenson, G" sort="Berenson, G" uniqKey="Berenson G" first="G" last="Berenson">G. Berenson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Brandt, H" sort="Brandt, H" uniqKey="Brandt H" first="H" last="Brandt">H. Brandt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crawford, S" sort="Crawford, S" uniqKey="Crawford S" first="S" last="Crawford">S. Crawford</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Crow, S" sort="Crow, S" uniqKey="Crow S" first="S" last="Crow">S. Crow</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Minnesota, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Fichter, M M" sort="Fichter, M M" uniqKey="Fichter M" first="M M" last="Fichter">M M Fichter</name><affiliation wicri:level="1"><nlm:affiliation>Roseneck Hospital for Behavioral Medicine, Prien, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Roseneck Hospital for Behavioral Medicine, Prien</wicri:regionArea><wicri:noRegion>Prien</wicri:noRegion><wicri:noRegion>Prien</wicri:noRegion><wicri:noRegion>Prien</wicri:noRegion></affiliation></author><author><name sortKey="Halmi, K A" sort="Halmi, K A" uniqKey="Halmi K" first="K A" last="Halmi">K A Halmi</name><affiliation wicri:level="2"><nlm:affiliation>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C" last="Johnson">C. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Eating Recovery Center, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eating Recovery Center, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Kaplan, A S" sort="Kaplan, A S" uniqKey="Kaplan A" first="A S" last="Kaplan">A S Kaplan</name><affiliation wicri:level="1"><nlm:affiliation>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="La Via, M" sort="La Via, M" uniqKey="La Via M" first="M" last="La Via">M. La Via</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Mitchell, J E" sort="Mitchell, J E" uniqKey="Mitchell J" first="J E" last="Mitchell">J E Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND</wicri:regionArea><placeName><region type="state">Dakota du Nord</region></placeName></affiliation></author><author><name sortKey="Strober, M" sort="Strober, M" uniqKey="Strober M" first="M" last="Strober">M. Strober</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rotondo, A" sort="Rotondo, A" uniqKey="Rotondo A" first="A" last="Rotondo">A. Rotondo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Treasure, J" sort="Treasure, J" uniqKey="Treasure J" first="J" last="Treasure">J. Treasure</name><affiliation wicri:level="4"><nlm:affiliation>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Woodside, D B" sort="Woodside, D B" uniqKey="Woodside D" first="D B" last="Woodside">D B Woodside</name><affiliation wicri:level="2"><nlm:affiliation>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bulik, C M" sort="Bulik, C M" uniqKey="Bulik C" first="C M" last="Bulik">C M Bulik</name><affiliation wicri:level="4"><nlm:affiliation>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Keel, P" sort="Keel, P" uniqKey="Keel P" first="P" last="Keel">P. Keel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Klump, K L" sort="Klump, K L" uniqKey="Klump K" first="K L" last="Klump">K L Klump</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, Michigan State University, East Lansing, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Michigan State University, East Lansing, MI</wicri:regionArea><placeName><region type="state">Michigan</region><settlement type="city">East Lansing</settlement></placeName><orgName type="university">Université d'État du Michigan</orgName></affiliation></author><author><name sortKey="Lilenfeld, L" sort="Lilenfeld, L" uniqKey="Lilenfeld L" first="L" last="Lilenfeld">L. Lilenfeld</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Plotnicov, K" sort="Plotnicov, K" uniqKey="Plotnicov K" first="K" last="Plotnicov">K. Plotnicov</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Topol, E J" sort="Topol, E J" uniqKey="Topol E" first="E J" last="Topol">E J Topol</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shih, P B" sort="Shih, P B" uniqKey="Shih P" first="P B" last="Shih">P B Shih</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Magistretti, P" sort="Magistretti, P" uniqKey="Magistretti P" first="P" last="Magistretti">P. Magistretti</name><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Bergen, A W" sort="Bergen, A W" uniqKey="Bergen A" first="A W" last="Bergen">A W Bergen</name><affiliation wicri:level="2"><nlm:affiliation>Center for Health Sciences, SRI International, Menlo Park, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health Sciences, SRI International, Menlo Park, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Berrettini, W" sort="Berrettini, W" uniqKey="Berrettini W" first="W" last="Berrettini">W. Berrettini</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kaye, W" sort="Kaye, W" uniqKey="Kaye W" first="W" last="Kaye">W. Kaye</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schork, N J" sort="Schork, N J" uniqKey="Schork N" first="N J" last="Schork">N J Schork</name><affiliation wicri:level="2"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="eISSN">1476-5578</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anorexia Nervosa (genetics)</term><term>Anorexia Nervosa (metabolism)</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Cholesterol (metabolism)</term><term>Cohort Studies</term><term>Epoxide Hydrolases (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Psychometrics</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anorexie mentale (génétique)</term><term>Anorexie mentale (métabolisme)</term><term>Cholestérol (métabolisme)</term><term>Epoxide hydrolase (génétique)</term><term>Femelle</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Psychométrie</term><term>Variation génétique</term><term>Études cas-témoins</term><term>Études de cohortes</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epoxide Hydrolases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anorexia Nervosa</term><term>European Continental Ancestry Group</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Anorexie mentale</term><term>Epoxide hydrolase</term><term>Population d'origine européenne</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anorexia Nervosa</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anorexie mentale</term><term>Cholestérol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Psychometrics</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Psychométrie</term><term>Variation génétique</term><term>Études cas-témoins</term><term>Études de cohortes</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Canton de Vaud</li><li>Caroline du Nord</li><li>Colorado</li><li>Dakota du Nord</li><li>District de Columbia</li><li>Floride</li><li>Grand Londres</li><li>Louisiane</li><li>Maryland</li><li>Michigan</li><li>Minnesota</li><li>Pennsylvanie</li><li>Toscane</li><li>État de New York</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li><li>East Lansing</li><li>Lausanne</li><li>Londres</li><li>Pise</li><li>Pittsburgh</li></settlement><orgName><li>Université d'État du Michigan</li><li>Université de Caroline du Nord à Chapel Hill</li><li>Université de Londres</li><li>Université de Pise</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Scott Van Zeeland, A A" sort="Scott Van Zeeland, A A" uniqKey="Scott Van Zeeland A" first="A A" last="Scott-Van Zeeland">A A Scott-Van Zeeland</name></region><name sortKey="Bansal, V" sort="Bansal, V" uniqKey="Bansal V" first="V" last="Bansal">V. Bansal</name><name sortKey="Berenson, G" sort="Berenson, G" uniqKey="Berenson G" first="G" last="Berenson">G. Berenson</name><name sortKey="Bergen, A W" sort="Bergen, A W" uniqKey="Bergen A" first="A W" last="Bergen">A W Bergen</name><name sortKey="Berrettini, W" sort="Berrettini, W" uniqKey="Berrettini W" first="W" last="Berrettini">W. Berrettini</name><name sortKey="Bloss, C S" sort="Bloss, C S" uniqKey="Bloss C" first="C S" last="Bloss">C S Bloss</name><name sortKey="Brandt, H" sort="Brandt, H" uniqKey="Brandt H" first="H" last="Brandt">H. Brandt</name><name sortKey="Bulik, C M" sort="Bulik, C M" uniqKey="Bulik C" first="C M" last="Bulik">C M Bulik</name><name sortKey="Carson, A" sort="Carson, A" uniqKey="Carson A" first="A" last="Carson">A. Carson</name><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W" last="Chen">W. Chen</name><name sortKey="Crawford, S" sort="Crawford, S" uniqKey="Crawford S" first="S" last="Crawford">S. Crawford</name><name sortKey="Crow, S" sort="Crow, S" uniqKey="Crow S" first="S" last="Crow">S. Crow</name><name sortKey="Darst, B F" sort="Darst, B F" uniqKey="Darst B" first="B F" last="Darst">B F Darst</name><name sortKey="Duvvuri, V" sort="Duvvuri, V" uniqKey="Duvvuri V" first="V" last="Duvvuri">V. Duvvuri</name><name sortKey="Galvez, L" sort="Galvez, L" uniqKey="Galvez L" first="L" last="Galvez">L. Galvez</name><name sortKey="Halmi, K A" sort="Halmi, K A" uniqKey="Halmi K" first="K A" last="Halmi">K A Halmi</name><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C" last="Johnson">C. Johnson</name><name sortKey="Kaye, W" sort="Kaye, W" uniqKey="Kaye W" first="W" last="Kaye">W. Kaye</name><name sortKey="Keel, P" sort="Keel, P" uniqKey="Keel P" first="P" last="Keel">P. Keel</name><name sortKey="Klump, K L" sort="Klump, K L" uniqKey="Klump K" first="K L" last="Klump">K L Klump</name><name sortKey="La Via, M" sort="La Via, M" uniqKey="La Via M" first="M" last="La Via">M. La Via</name><name sortKey="Levy, S" sort="Levy, S" uniqKey="Levy S" first="S" last="Levy">S. Levy</name><name sortKey="Libiger, O" sort="Libiger, O" uniqKey="Libiger O" first="O" last="Libiger">O. Libiger</name><name sortKey="Lilenfeld, L" sort="Lilenfeld, L" uniqKey="Lilenfeld L" first="L" last="Lilenfeld">L. Lilenfeld</name><name sortKey="Mitchell, J E" sort="Mitchell, J E" uniqKey="Mitchell J" first="J E" last="Mitchell">J E Mitchell</name><name sortKey="Murray, S" sort="Murray, S" uniqKey="Murray S" first="S" last="Murray">S. Murray</name><name sortKey="Pham, P" sort="Pham, P" uniqKey="Pham P" first="P" last="Pham">P. Pham</name><name sortKey="Phillips, T" sort="Phillips, T" uniqKey="Phillips T" first="T" last="Phillips">T. Phillips</name><name sortKey="Plotnicov, K" sort="Plotnicov, K" uniqKey="Plotnicov K" first="K" last="Plotnicov">K. Plotnicov</name><name sortKey="Schork, N J" sort="Schork, N J" uniqKey="Schork N" first="N J" last="Schork">N J Schork</name><name sortKey="Shih, P B" sort="Shih, P B" uniqKey="Shih P" first="P B" last="Shih">P B Shih</name><name sortKey="Smith, E N" sort="Smith, E N" uniqKey="Smith E" first="E N" last="Smith">E N Smith</name><name sortKey="Srinivasan, S" sort="Srinivasan, S" uniqKey="Srinivasan S" first="S" last="Srinivasan">S. Srinivasan</name><name sortKey="Strober, M" sort="Strober, M" uniqKey="Strober M" first="M" last="Strober">M. Strober</name><name sortKey="Tewhey, R" sort="Tewhey, R" uniqKey="Tewhey R" first="R" last="Tewhey">R. Tewhey</name><name sortKey="Tisch, R" sort="Tisch, R" uniqKey="Tisch R" first="R" last="Tisch">R. Tisch</name><name sortKey="Topol, E J" sort="Topol, E J" uniqKey="Topol E" first="E J" last="Topol">E J Topol</name><name sortKey="Torkamani, A" sort="Torkamani, A" uniqKey="Torkamani A" first="A" last="Torkamani">A. Torkamani</name><name sortKey="Villarasa, N" sort="Villarasa, N" uniqKey="Villarasa N" first="N" last="Villarasa">N. Villarasa</name><name sortKey="Wineinger, N" sort="Wineinger, N" uniqKey="Wineinger N" first="N" last="Wineinger">N. Wineinger</name><name sortKey="Woodside, D B" sort="Woodside, D B" uniqKey="Woodside D" first="D B" last="Woodside">D B Woodside</name><name sortKey="Zhang, G" sort="Zhang, G" uniqKey="Zhang G" first="G" last="Zhang">G. Zhang</name></country><country name="Allemagne"><noRegion><name sortKey="Fichter, M M" sort="Fichter, M M" uniqKey="Fichter M" first="M M" last="Fichter">M M Fichter</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Kaplan, A S" sort="Kaplan, A S" uniqKey="Kaplan A" first="A S" last="Kaplan">A S Kaplan</name></noRegion></country><country name="Italie"><region name="Toscane"><name sortKey="Rotondo, A" sort="Rotondo, A" uniqKey="Rotondo A" first="A" last="Rotondo">A. Rotondo</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Treasure, J" sort="Treasure, J" uniqKey="Treasure J" first="J" last="Treasure">J. Treasure</name></region></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Magistretti, P" sort="Magistretti, P" uniqKey="Magistretti P" first="P" last="Magistretti">P. Magistretti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F25 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002F25 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23999524
|texte= Evidence for the role of EPHX2 gene variants in anorexia nervosa.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23999524" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |